Certain film franchises have had toxic fans issuing death threats to filmmakers/cast members, and anime staff/voice actors have faced similar threats (many staff/VAs for the anime Darling in the FranXX received them after a certain episode aired). Fan bases of any medium contain people who become too obsessed with them and if a new installment or such upsets them greatly they think that somehow justifies making the people involved feel threatened or relentlessly harass them.
Toxic Star Wars fans infamously were guilty of giving Jar Jar actor Ahmed Best suicidal depression for a year, and drove Jake Lloyd (kid Anakin) kind of nuts. Mark Hammil told them to stop that and leave the cast alone, but lo and behold they were back at it again when the new movies came out. Thankfully the verbal attacks weren't as severe this time (that we know of) but it shows a depressing image of certain "fans" refusing to mature and learn how to properly behave even when the original lead actor of the series tells them to.
My most hated movie is Silent Hill: Revelations. However, at no point did I ever even consider verbally attacking those who made the film if I ever met one of them, nor did I think less of those who enjoyed it. And hey, one of my closest friends liked the film, and it's all good. Life's too short to belittle people over different opinions over fictional stories, and it doesn't make you more of a "true fan" by doing so when in reality you're just being an obnoxious asshole.
Also worth mentioning, the attack on the anime studio Kyoto Animation is certainly the most tragic event regarding an entertainment creative workplace in recent years that immediately comes to mind. Granted, the attack was carried out by someone who wrongfully accused the studio of plagiarizing his novel, but still it felt relevant to mention as many lives were lost in this tragedy.