Anyone else playing on very hard/hardcore? I've revised my character a bit after some more play through and analysis. Skill points are harder to come by with the lower bonus from INT, so I'm thinking a higher INT will be generally beneficial. I'm pretty sure you get 15 extra skill points per point in INT. It turns out the END mod counts against your mod total, so you need 7 base END to get 6 stats plus the 4 DT mod. This gives you an extremely strong character with high crit and lots of skill points to spend.
Final base stats after modding, without any gear on = 8 STR, 6 PER, 8 END, 1 CHR, 8 INT, 6 AGI, 9 LCK, +4 DT
As for skills, here's what I've taken so far. My character is capable of tearing up deathclaws on very hard with some relatively plain weapons just by procing crits all the time.
01 Fast Shot and Built to Destroy
02 Confirmed Bachelor
04 Rapid Reloads
06 Bloody Mess
08 Cowboy
10 Finesse
12 Shotgun Surgeon
14 Purifier
16 Better Criticals
18 Sniper
Working towards Ninja and Jury Rigging. Not sure on the last 3 slots but probably VATS related stuff.