Cocaine would do the trick.
Nah man, crystal meth, krokodile, or just straight up heroine. It's all good.
But the real superdrug is patience, and executing will power to cheat less with progress, not more. Otherwise you're just using the old weight and its metabolic rate as the offset / baseline for where you think you should be in terms of calorie intake to body weight. Metabolism actually relates to body weight (from
Kevin Hall's presentation on that), and so with each significant loss your metabolic rate also decreases, meaning you should decrease your expected caloric intake with time and progress, not use the exact same number as when you were heavier.
(because that's the maintenance number for that higher weight, not the lower weight. There can a full 1000 calorie difference between the two rates too, from 3k at 200+lbs to a measly 2k at 150lbs. So adapt your rate with the loss, and you need to cheat less with loss, not more)
What I think is actually more interesting about that data from Hall, is that it might explain why 'bulking' even works at all. Not because of some crazy 'this is what your body does, motherfucker!' theory, but simply the increase in metabolism from an increase in body weight, affecting the rates of building up muscle versus de-building them. Like temporarily tipping the scale towards the first, whereas a subsequent cut may not significantly increase the latter half of that equation.
I really dislike all those "this is how a cell works" micro-scale empirical findings turned into macro level theories, since that's not how you're supposed to connect those dots. Macro data, macro theory. Micro data, micro theory. Don't cross the streams, that's bad science.
I'm kind of writing an alternate 'diet guide' because I saw that the bestsellers on Amazon are all "EPIC TRANSFORMATION" type diets, which is basically the way to get six months loss, then regain it all in three years. If I'm completely wrong here, I would like to hear before I press 'publish'. Not that it matters for self-published crap (and oh boy is it all crap), but still, I just want to see where that goes.