Go mini ITX. Both ASUS's and ASRock's Z77 ITX boards are phenomenal, and offer great overclocking potential. Pair with a Silverstone FT03 mini if you want a fancy case, or a BitFenix Prodigy if you want a hassle-free build that can run super cool and quiet. The included fans in the Prodigy are silent operating, and you can fit any cooler you want in it. Still modding one that I received from BitFenix a little while ago, and it's one of my most favorite cases I've ever tinkered with.
If you want more than one expansion slot though and therefore want to stick with mATX, Fractal Arc Mini, Define Mini, Lian Li PC-A04, PC-V600, PC-V354, Silverstone FT03, TJ08E, and PS07 are all great cases. TJ08E, A04, V600, and Arc Mini are the most hassle free in terms of not needing to choose parts carefully.
Slacker!
(throwin' stones in a glass house here)