Things I didn't know about this patch: I never play Renekton, and in a couple of ARAMs or whatever it was driving me nuts how his ult wouldn't work until I pressed it 4 times or so.
Today I tried pressing R, turning off smartcast for R, pressing R again with smartcast off, pressing alt-R, and manually clicking the button. None of those worked.
So as far as I can tell, unless I had some weird glitch based on my previous keyboard config, Renekton R only works if you hold the mouse over Renekton as you press R. :|