I do think S. Links will need to evolve dynamically, whether it be going deeper into cross-encounter stuff with other links, more variables in what actually happens with their story and potential ramifications for that particular character.
(this would probably apply more to sidestory stuff than the main quest, as going with variables on something like a Persona main story would lead to madness. Though Atlus did kind of hint at this stuff with the Killer's Assistant end in Golden.)
It's a fine line though, toeing between keeping things dynamic and not taking options away from the player. I think that's why P4 had such fewer Reverse S.Links (only Moon, IIRC). You as the player are constrained enough by way of the limiting number of days both as part of the story and gameplay.
For example, taking away or reversing potential s.links because you hadn't say, visited X person in a few weeks or requiring semi-special apology multi-day quests/scenes sounds dynamic and cool, but that would frustrate a good number of players to no end, especially newer players who aren't min-maxing s.links or stats.
Speaking of personal stats, think we'll get more/same/less than P4's 5? I liked it better than 3's 3, felt more balanced.