http://www.nintendojo.com/infocus/view_item.php?1096417842
According to Kobayashi, Resident Evil 4 marks the end of a saga. While the series itself will continue, this shall be the last time (supposedly) that we'll see the Umbrella Corporation involved in any sort of way. Indeed, as we said in our preview in early 2003 -- Resident Evil 4 is a nefarious, narrative climax. It is, for all intents and purposes, the ultimate Resident Evil to date.
Kobayashi also confirmed that Resident Evil 4 will have other playable characters aside from Leon, the now ubiquitous protagonist.
Finally, in response to the question on all our minds -- whether or not Resident Evil 5 will see a release on the Nintendo Revolution -- Kobayashi stated that there is no reason to suspect that Capcom will continue releasing Resident Evil titles on Nintendo's consoles. However, he seemed to suggest that the ultimate decision will be based on retail performance of Resident Evil 4.