In addition to Pikmin 3, F-Zero and Miyamoto's "Mermaids" for Cafe at E3 2011, I also suspect seeing Skyward Sword make the next-gen jump.
Nintendo likes repeating things that work out for them; releasing two TP SKUs worked well and got the Wii off to a strong start. (Wasn't the attach rate nearly 1:1 on launch day?) Plus, TP had more exposures as a GCN game (E3 2004, GDC 2005, E3 2005) before being delayed a year for Wii (E3 2006). As has been asked, what's to stop Nintendo doing it again? It would certainly explain why outside of a GDC trailer Nintendo has been virtually silent about the title. It's like they're avoiding too much talk of it as a Wii title to help make a Cafe version (or conversion) more palatable to the fans who've been waiting so long.
Also, re: the Wii-to-Cafe jump being so massive -- if they do two SKUs, then the Cafe version of SS may be just like a Wii game running on Dolphin, albeit fine-tuned for HD displays, and with the new control interface perks.
If on the other hand SS remains Wii-only, I see Wii having a strong E3 lineup, if NOA localizes some games. The potential is certainly there: Skyward Sword, Wii Play: Motion, Rhythm Heaven, Fatal Frame 2r, Kirby Wii, Xenoblade Chronicles and The Last Story.
Then for the 3DS there's the Mario trifecta -- Super Mario 3D, Mario Kart 3D and Paper Mario -- plus OoT 3D, Star Fox 64 3D, Mercenaries 3D, Revelations, MGS3, Kid Icarus Uprising, Animal Crossing, etc.
If you like Nintendo, it should be a killer E3. The guarantee of a Super Mario 3D appearance alone makes it a winner.