Nope.
I just recently rebought one after a two year hiatus. (Or my ex stealing/pawning mine)
Donkeys Kong Country, Fragile Dreams, Opoona, Monster Hunter Tri, Skyward Swords, Lost in Shadow, Mario Galaxy 2 and Silent Hill Shattered Memories are what I picked up with the system. (All but MoHun and Opoona new to me, but only played a tiny bit of these two.)
These should keep me busy for a long long time.