Kill La Kill for example is a serious story with comedic undertones. Iron Man 3 is a comedy with action tones. Futurama is a goofball comedy with some minor degree of continuity, similar to the Simpsons. Archer is a serial comedic action cartoon, however American Dad isn't serial. Noragami, another BONES show, is a straight up action show with some light comedic scenes in there.
Some comedies are laugh out loud, while others just have a humorous environments/atmospheres. It's damn near impossible to say what a comedy should and shouldn't do. There are some episodes of Futurama or Archer where I don't laugh at all but they are my favorite episodes in the franchise.