So I'm trying to go through the main game (non-challenges) beating Mom's Heart with each of the characters, then Satan, then etc. If I think I have a run that'll beat Satan, I go ahead and go for it after Mom's heart.
So far, I got Isaac, Azazel, Lazarus (?!?), and just now Judas.
This Judas run was incredible. Nothing exactly BROKEN in it, but.. well, here's how the items went:
1: Quad Shot
2: Yum <3
3: Dark Matter (Traded Yum for it, because why not?)
4: Speedball
5: Technology
6: Wafer
7: Halo
8: Bent Spoon
And at that point, I didn't care what I got anymore, because I was ripping through rooms with no effort at all. I only took damage from accidentally running into spikes in the Womb (already have Mama's Boy from Azazel). It Lives was run down in a few seconds. Satan only lasted longer because I practiced dodging his second form's shots.
In short, that was one of the most broken builds I've gotten in a while. I'm loving it. Wish I had more time to sink into it.
Edit: Forgot to mention that my second Devil room gave me 2 Luck Up pills, and 2 Speed Up pills. Craaaaaaack~