I for one, never played the Mass Effect series for several reasons:
1. I did not own an Xbox 360 or a capable PC when the first part came out in 2007.
2. By the time the series came out on PS3, I had a backlog of games to finish. By the time the trilogy was affordable to me (both in price and time), I upgraded to PS4.
3. I enjoy sci-fi and have a fascination of exploring the galaxy (which Destiny failed to deliver in), however I'm not big on relationship driven RPGs, something Bioware tends to be very known for. Same reason why I have yet to try Persona 4, as people I know won't stop pestering me about the franchise.
4. I'm not particularly fond of going back to my PS3, which is currently at my friends possession to play through the trilogy due to rather being used to the PS4. If a remaster of the trilogy comes out, I might look into it.
5. I tend to have a very short attention span when it comes to long games, especially RPGs. If a game doesn't grab my attention within the first few hours, I tend to get weary and lose interest.
All that being said, will the new set of games take place in an entirely different setup than what happened in the previous trilogy? Would I have to play the original trilogy to have an idea of what's going on? Finally, would I have to accept the nature of the games being focused on building relationships or just not bother entirely? I do enjoy some relationship building elements, such as making friends, however life simulation is something that I detest. I do want to give the Mass Effect series and Persona 4 a chance before I completely negate them from my bucket list.
Thank you if anyone read this drivel and could give me some feedback on the general franchise and if I should remain interested in taking a look at it eventually or just move onto other things.
Best wishes.