And once you do it once, you can save the game and use that as starting point for other runs.
Sapienza still needs one more update. I couldn't do the detective challenge of disposing of Francesca because some guards have X-ray vision and can see through several meters of solid matter into the tunnel where i'm supposed to kill her and dispose her. Even if I kill her from a corner where I'm not seen, the moment I touch the body I'm found by a guy who sees me magically through the floor.
Also, I had one CTD in that area, the first one for me.