After checking out the Demon Hunter subreddit, I decided to try this Grenade setup that apparently most DH's are using for high MP runs. I'm already kind of annoyed at having to use traps at high MP levels (not my playstyle), but figured I'd check this out; the upside to the setup is that gear-wise it's more or less identical to my current typical Manticore setup except you have to use a Calamity for it.
All I did was buy a 2 million Calamity off the AH and stuck a Flawless Star Ruby I had lying around in it, and swapped out Hungering Arrow/Bola Shot (was messing around with that) for Grenades. Holy fuck it is HILARIOUS, I am blown away. With this so-so Calamity my DPS is about 180k with about 480k eHP, but I went straight into MP10 Act 3 and just facerolled it. The suicide bomber guys in the Keeps are a serious issue (and the only thing that actually killed me), and I have to agree with the sentiment out there that any sort of ranged/teleport enemies are incredibly annoying with the build and in some cases are worth skipping, but other than that it was a joke. Did an typical Act 3 run with it, and outside of some Elites being really annoying (and in hindsight probably should be skipped) this is a total gamechanger. Goddamn. And I'm only running the super basic setup, I'm not even incorporating Caltrops or Turrets into it like most people are at high levels. I'm going to have to investigate this more tomorrow, but this may completely turn me around on my DH. I feel like I need to sit down.