Here are the things I can only give you one-sentence impressions on.
Speed: the phone feels entirely quick, but that's also down to how HTC speeds up the animations at the OS level to give this perception, and I'll have to spend more time with it before I really decide if it's quick or if HTC really hasn't been able to work any more magic with the so-far so-so Snapdragon 820 than anyone else has yet.
Display: Oversaturated with some fairly noticeable color casting at off angles, and I'm not especially impressed with sunlight performance right now (polarization also seems a bit odd?), but the blue-cast is definitely less of an issue this go around.
Camera: I'm already having issues with pink-ish looking whites in indoor and low-light shots that simply don't occur with the G5 and S7, but I need to spend a lot more time with the camera to figure out what's what, but there's no way it could be worse than the M9 or A9... I hope. (I can't share any pictures, sorry.)
Audio: I'm very impressed with the dual speakers, but some more head to heads need to happen for me to give a final verdict, though I'm quite optimistic - I haven't tested headphone audio just yet.
Battery: Too early to tell.
Overall: The HTC 10 feels like a much greater step forward than either the M8 or M9, but I'm not sure it feels like a phone that necessarily belongs in 2016, which kind of echoes how I felt about the G5 (again, I still need more time with it).