Going off of the Beta, I think some of the best things about this game are the subtleties.
1) I love that there are rarely any traditional loading screens. If I remember correctly, they only pop up once you choose your character at the very beginning. All other loading times are hidden beneath pretty nice eye candy of ships flying through space.
2) I like that the multiplayer, single player and co-op are not stuck behind some menu but are all a part of the world you inhabit. You don't have to go out to the title screen to access a different game within a game.
3) I like that there are no digital menus, but all cursor based navigated with the analogue stick. I didn't like it at first, it took a little to get used to, but it keeps your thumb always on the analogue stick and gives a more organic feel (if that makes sense).