My Monk is just completely ridiculous now. He uses Fist of Thunder with the lightning, so that shoots lightning everywhere, but then I have a 39% chance to prov chain lightning, and then a 15% chance to get the conduit shrine power hitting enemies everywhere for 640% weapon damage for 3 seconds, but my attack speed is +25% to begin with then +75% once I get a hit in, and I think the lightning hits count so it procs all the time. Then my tempest rush is lightning, and the hits from that must count for the proc on the conduit because it starts even faster from that.
My punches are doing +300% plus 54% on the skill plus 29% on lightning (and yes that applies to all the lightning mentioned). Then I also have the stinky pants that deal 550% per second to enemies within 15 yards. But here is the real kicker... I have +0.89% increase of damage of all damage against an enemy per each hit. It apparently doesn't have to be consecutive against one enemy, but just any hit on any enemy makes then more vulnerable, so all these punches and especially all the lightning is perpetually making all of them more vulnerable every second. And then I'm still applying exploding palm with every 3rd punch, and have my 14x damage-each-strike 14 sided strike to melt screens and bosses.
I also decided to forego the get out of death skill and -20% cooldowns for better resistances so my toughness is now 36 million. I don't really have to worry about magic zones on T3, not even arcane. I want to give GR21 another shot now.
Edit: GR22 done in 10mins killing most enemies and getting a bit lost. No close calls. This build is the shit and it's only half done.