For the time thing, the last endurance run was Shenmue. All the other ERs happened when they weren't at CBSi yet, so they had more time. Now think about what happened with the Shenmue ER. They dropped it out of the blue because they were recording it in secret the entire time Dan was in NY, which was awesome. But don't you remember everyone here questioning what the hell Dan was doing when he was visiting GBE? Outside of podcasts, the content we got out of GBE while Dan was visiting was:
3 QLs
Summer Games Olympiad
GBE Game Design Academy
Hitman Double Agent
A VinnyVania episode
for an entire month. No GBE playdates either. Compare that to their current output. That's the content output you're looking at if you have Jeff and Vinny do a P5 ER, and consider that a P5 ER would be probably 4 times as long as a Shenmue ER.
Now maybe they only do it every so often, or once a week. That could work. But an Endurance Run is never going to happen. And they don't show enough interest to do it once a week either.
And the FF thing wasn't about that, it's just that there are people who love one game but the other doesn't grab them because it doesn't have the same world or characters. It's not like Jeff didn't play Persona 5. He played it for an hour and a half, and it didn't do enough to interest him. You can say that's unfair, but if he isn't into the characters or the story, especially compared to P4, he's not going to play further and try to get into it