I'd probably ignore Vlad. He isn't bad, but he finally got put in line with the utility his skills bring.
Annie and Brand are similar enough. Massive burst damage. If you are decent timing, I'd say Brand is the better choice. Better range and not as reliant on the ult. But Annie with a Tibberz ult ready means back the fuck up.
Ori is top tier now, most likely going be nerf. She has a very strong 1 2 combo + the movement speed burst/shield.
Swain is a bit more situational. If they are running a heavy ignite team, your jungle needs blue, etc. I'd rather not play him. If you can get him blue, farm well enough, and last through the ignites. He is going to solo teams.
Cass is probably the strongest early laner. Similar to Urgot, she can zone very well and is just a pain to go up against
LeBlac is a pure sink or swim character. End the game in 10-15 minutes, or face being an easy kill for the rest of it.
Fiddle is the jungle caster. He is pretty good all the way through unless you get a bad start. The other team constantly has to watch out for that ult(Extra warding), and you have a really annoying combo that lets do quite a bit of damage.
Morg/Lux, Morg is more damage while Lux is more utility.