According to a recent edition of Wrestling Observer Radio, Kalisto will be defending the United States Title at WrestleMania 32, however he will not be facing former Champion Alberto Del Rio. There was speculation Kalisto and Del Rio would continue their feud into Mania, but that is not currently the plan for the U.S. Champ.
While not confirmed and speculative at this point, its possible Ryback could be an opponent for Kalisto at the big PPV this year. As we just noted, Ryback is booked in U.S. Title Triple Threat matches against Kalisto and Del Rio at upcoming live events, and with The Big Guy teasing a possible heel turn as of late, it could be a match option.