Tried that the other night. It's amazing. Think I might just roll with flame and cryo, distruptor later when I get the perk to unlock extra consumable slots. Even the scorpion SMG does a good job against shields.
Yeah, I'm running a combat enhanced biotic build (only using passive combat skills: pistol, AR and fitness), and the Pathfinder SMG with disruptor ammo is ridiculous. I crafted a level IV with clip size augs and mods and it holds 149 rounds per clip. Very stable too, almost no kickback.