The biggest problem is NoA.
When NoA lost key staff (Arakawa, Howard L, etc) and lost some partners (Factor 5, RARE, Left Field, etc), things went down.
C'mon, the two biggest studios from west are Next Level and Retro, that are making games that Japanese people could do.
But that's not the only problem. NoA being powerless - or just stupid, Nintendo lost contact with western publishers. It's strange that, except from Ubisoft, nobody rode the Wii sales train. Even japanese companies didn't invest on Wii when it was the biggest thing ever.
NoA is terrible with consumers too. Why should I buy a Nintendo console if I even don't know if some great japanese games is coming west? While I understand why Captain Rainbow wasn't released on USA (sadly), there is no forgiveness about what happened to Xenoblade, Last Story and Pandora's Town. 3DS have this problem too, I know that Dragon Quest VII is a Square-Enix game, but Nintendo should be forcing Square-Enix to at least ANNOUNCE the game in USA. (Let's not talk about DQX, please).
Wii U have BIG branding and marketing problems, this should be addressed.
And Nintendo should be moneyhatting wester publishers too, not just Platinum.
I really expect that will be a desperate Direct next week (usually we have before these meetings, right?) and I really want to see some progress on games like SMTxFE, Yoshi's Yarn, X, Bayonetta 2, Mario Kart and Smash. Bros. And, of course, TONS of new announcements.
There's no time to lose, Nintendo should put all cards on table and build some HYPE. It's already too late =/