I'm -1.25 sph, -2.50 cyl for both eyes and using my friend's was rough. Not impossible but not something I'd be able to enjoy a game with.
Shit. Seeing as I have to stick my face about a foot in front of my 1080p monitor to read text without strain, I'm probably better off waiting for next gen. I know the Vive and PSVR are better for glasses, but cost/comfort/etc.