Prototype's main missions and the web of intrigue (even though it's largely just go here, consume this person) are enjoyable and ultimately are what are driving me to play through the game. I find the openworld missions are pretty hit and miss, the only activities I find truly entertaining out of the lot are the desturction marathons where you have to kill x number of enemies in y amount of time. Everything else is usually one and done, no matter how I place (although half of the activities have been cleared with a gold). I don't really feel driven to play most of the openworld events because I don't find them to be particularly fun and I always have more than enough points to buy every ability as they become available for purchase.
I really don't like that every open world activity in Prototype is timed and often for no apparent reason, it's just a contrived constraint to place on most missions. Get the the military base, consume the right person to gain entry in x amount of time, get access to the base, time limit vanishes. Why even have a time limit for that mission in the first place? It's not even part of the mission goal to arrive at the location in a certain amount of time. It's just contrived, which I think is a complaint I can level at a lot of Prototypes design, mission structure and mechanics.
The core gameplay is fun but I find the biggest difference between Prototype 1 and 2 is how much you have to rely on weapons and vehicles during combat in the first game. You're powerful, but not that powerful if you have to stoop to use standard weapons and vehicles. Which is kind of a shame. I kinda like that those things are largely just an option for Prototype 2 and you can pretty much just play through the game with your powers. That;s what separates Prototype from other games, the crazy powers. I wish Prototype 2 had the badass armor that Alex Mercer unlocks about half-way through the first game.
Looking at the stats I'm 9 hours in and roughly half way done the game (15 out of 31 missions complete). It's been a very Prototype-y weekend.