A couple thoughts, I'm not too far in (I just found the downed plane)...
Swinging is awesome. There's a couple times where you kick from no momentum to sudden, but that's to benefit the player, so no complaints there. Even if you fall, locking on to something to save your ass usually isn't a problem. It's fun to just tool around the areas at times, completely ignoring the enemies and just swinging from point to point seamlessly.
But then that leads to the radiation issue. Sometimes it's not as clear-cut as you'd expect, and that stuff will kill you in less than a second if you get too deep into it. The problem is that there are deep spots all over the place, in some confusing locations. And way too often on the top of buildings. Way, way too often you can scale up the side of a building just fine, but they block off the actual top of the building, and if you jump up there you're a toasty sandwich. Fire is pretty bad about that too, you don't have to be "touching" it to be hit by it, and before you can move away it's often too late. And sometimes you could be going the right way and still get a minor radiation warning, scaring you off or confusing your progress. I was running up a building's interior and got it when I was close to one side of the hall.
Ammo is ridiculously scarce (picking up an ammo item and getting 2 shots is nearly pointless), and why does the default gun have ammo anyway? The original didn't force that on you, nor the remake. It makes you use your arm a lot more, which isn't terrible, but you shouldn't have to watch the primary pea shooter like that. All the ammo pickups should be on the secondary weapons only.
I got the "kick rubble" move, and it's so satisfying. The first time I got it, I found myself kicking forklifts, steel crates, barrels and corpses down the hallway en masse, crushing anything that dared threaten Mr. Rad. They really sell it with the sound and shake, too.
I'm not as fond of Nathan's voice, I honestly first expected Super Joe's voice to be Rad's. Either way, I'm tooling around in goofy 80s style, because that's the only way to go. Occasionally I get a Blasto vibe from Nathan's commentary, but sometimes he punctuates a string of good swings well, or puts a nice cap on a firefight.
It's an enjoyable game, but plot-wise it feels like it doesn't have very good landmark points yet. It keeps going and going and stretching out and I still feel like I'm in the first area, which I probably am. It took me three or four segments I believe just to get to the downed plane, so the pacing just feels strange. Either way, the loading so far hasn't been an issue. It could always be better, but it goes by fast enough.
Going to play more later. I'm grabbing collectables and doing challenges when they're easy enough, but I'm not trying for a full playthrough this time. That will come later, preferably if a patch for saving them comes too.