Investigation tips. I've only done four but here are my non-spoiler tips:
1) Google search it your friend unless you're an all star Jeopardy champ. Using it to look up the periodic table is not cheating. Looking up the YouTube vids that walks you through everything step by step is
As a last resort you can ask for a hint from a cabal mate. I'd avoid general because you might get a rat bastard yelling thpoilerz.
2) Check your inventory. Sometimes things you find or get from quests will come into play.
3) Put your gun down and put your thinking cap on. These are hard, very hard. I find it best to take a break before tackling one.
4) I prefer doing the investigations after I've done most if not all of the zone. You understand the zone better, have seen the sight and in general have a far better chance of solving it.
5) Read you map. Shapes or words could be the key. Know your land marks.
6) Every TOOL at your disposal might come into play. Y you ask? Yes Y indeed.
7) If you hit a dead wall, stop and doing something else, explore, repeat a quest, go to bed. The solution might come to you. The reward is worth the time by a landslide.
8) Think before you click that yellow highlighted object. You can get answers wrong that will delay you.
9) Take notes during the verbal part of the quests and then revisit the quest log and read the quest description.
10) If its glowing yellow but you can't click on it try harder. Sometime the clicky icon is finicky as hell. Don't pass up a key clue because you think the yellow clicky object is bugged. Move the mouse around and find the sweet spot.