I'm looking for a short story I read six years or so ago in a sci-fi anthology:
-Humans branch out into the galaxy, and find that it is dominated by an alien intelligence that is basically all-powerful, and sinister. This force has already enslaved all other intelligent life forms.
-Humans and their colony ships are hunted to near extinction, always attempting to adapt, genetically modify themselves, and hide themselves away.
-They're always found and systematically erradicated, even though they put up a fight. One branch of the story depicts the humans, heavily modified for a high-G planet, being found and attacked.
-Towards the end of the story, one lone ship manages to find the "headquarters" of the alien race, and meets the "leader" of the alien forces. I forget exactly what happens, but the gist is that there is no hope for the human race, they are but play-things to the alien.
Maybe someone will recognize this. Worth a shot, because I've searched for quite awhile and never rediscovered the name.