That depends. They might not lose, but even so most don't have a plot device which demands the hero can never lose.
I think the plot device is being exaggerated here. They never out-and-out say "Oh Takuto can't lose." I mean, during the entire West Maiden arc there's no reason to believe that since we saw that the North Maiden was free to leave and live a perfectly normal life and the villains were not yet at World Domination phase. Heck, even at this late stage in the show I'm not really getting that, since we've seen two Maidens walk away just fine.