Just to let you guys know.
I played the entire game 16:9. Now I'm playing as Chris via 4:3.
4:3 is so much better.
The problem with 16:9 is that it has to effectively zoom in on the image in order to make it 'wide-screen.'
So you have an upscaled 480p image that's being zoomed and maybe even overscanned if you're tv isn't calibrated properly which equates to vomit and shit on the screen. It's a testament the game can still manage to look good in most areas despite this.
However, putting it at 4:3 effectively gets ride of the forced overscanning (which is what fake 16:9 effectively is)
So, put it ton 4:3. You stop giving a fuck about the blacks bars on the side after about 10 minutes. Trust me....I SAID TRUST ME!!