I went with no on my poll. The reasons I think it might not even be half the success of the Switch :
In the last 2 decades, Nintendo found success in "gimmicks". Motion control, second screen, 3D, etc. They were able to capture a crowd that does not buy video games, normally. I was working for 6 years in a video games store from 2002 to 2008. I saw the crowd of old people buying DS for Brain Training. Kids wanting it for Nintendogs, parents buying a Wii "to get the kids moving". That was huge interest, but always temporary interest.
Then the Wii U happened. People think the main reason Wii U didn't sell well was the name. I disagree, I think that it didn't sell well mainly because people didn't understand how different it was from the Wii. It used the same motion controllers, similar form factor, etc. HD graphics wasn't enough. And it's not because Wii U didn't have good games. It had the usual slew of Nintendo games (that became huge successes when re-released on Switch.)
From the leaks we had so far, Switch 2 seems to be a more powerful Switch, something the majority of the Nintendo buyers clearly don't care about. As a lot of the Switch buyers are parents... I think a lot will scratch their heads at why they should something similar to what their kids already have.
Also, a lot of young people now play on mobile, so it might affect it.
I don't think it will fail per se, but I think it will be far less successful than the Switch.