I would play Yeldon... and, let me tell you something, I don't think the Jaguars fall behind in that game and abandon anything. I think the Colts are trash this year and it's not like Jacksonville has lost to a bad team or anything. They've lost to the Panthers and Patriots... both of whom are 3-0.
On top of that there's a decent chance Luck doesn't play... or, if he starts, plays the entire game. I'm leaning towards the favorites in most of my picks this week, but if I'm leaning towards an upset anywhere, it's there. And I don't care if the Colts have won something like 15 straight in that division. This isn't nearly the same Colts team.