Travis Day talks about possible modes such as endless dungeons (
http://us.battle.net/d3/en/forum/topic/8480518561#16)
and Lylirra talks about a new gameplay mechanic for consoles "power up globes" (
http://us.battle.net/d3/en/forum/topic/8197591084?page=6#106)
"It's what we call a "power up" globe. Basically, there's a small chance that whenever a health globe drops it'll turn into a power up globe instead. These globes can provide the player with one of several small, temporary buffs (+MF/GF, +movement speed, +attack speed, etc) when picked up and last for very short period of time. They're similar to Shrine buffs, but are designed to give players a quick boost during the middle of combat, rather than something you take from fight to fight.
Right now, there aren't any plans to bring power up globes to the PC, but that of course may change as we continue testing and poring through your feedback.
"