Has My Brother always been skyped or did it begin as a locally recorded podcast?
Are any of them in the same room or are they all remote?
Are any of the hosts a non-brother that doesn't know the rest of them as well as the brothers?
I think you're cherry picking on podcast that makes it work.
No offence to Patrick, but his style is more of an informative monologue rather than the quick witted exchange of Jeff and Vinny.
As far as I know, always remotely, all remote, none a non-brother.
In regards to the always remotely, is your argument that the podcast will only be noticeably worse because it will be relative to what we're used to? Because relatively worse does not equal bad.
In regards to the non-brother part, I think Vinny probably knows the majority of the people on the Bombcast pretty damn well, not that that is wholly relevant.
And because I'm not just cherry picking, you can also check out The Besties, which includes Justin and Griffin, but also Chris Plante and Russ Frushtick who aren't brothers, but still from other sides of the country.
If that still isn't enough for you, check out The Comedy Button, where Anthony Gallegos has been Skyping in (and is the ONLY one skypin in) and it's effective enough that he is even the host of the show. Those who listen to the Comedy Button know that it's often an even faster paced show than the bombcast, with people building on one another constantly.