About the how/if of Snake's death:
I'm not ruling out a "heroic" suicide (even though it's been telegraphed so obviously in the trailers). Think about it as Snake going out on his own terms instead of whenever FoxDie randomly stops his heart.
I imagine if this happens there will be a huge rift about whether this was a good decision, seeing as how suicide is generally considered "cowardly", selfish and the "easy way out" in Western culture, while in Japan it is often seen as a courageous, selfless, honorable and moral act.
Should be interesting. More interesting than him dying of artificial old age or just being shot in combat.