My main irk about the show is that its focus does not become clear until very late in the game, and you end up feeling like you've been strung along.
At first, it's a show about a murder that police swept under the rug.
Oh wait no, there was no murder. Now it's a treasure hunt to find this guy's secret fortune of gold bars.
Oh wait no, the hunt for the gold has turned up nothing. Now it's a show about a probate battle between a suicide victim's close friends and his distant greedy relatives.
Oh wait no, Rita just seems to be a well-meaning person who just wants to protect John's assets from being pilfered. Now it's a show about how the corrupt local police are trying to screw her out of the estate.
Oh wait no, the police and city officials are mostly neutral. Now it's just a character study about a savant, and how he became a repressed, obsessed misanthrope who pushed away everyone who might have cared about him.
All the intrigue surrounding John's death never really amounts to much, but it's played up at every turn. This might be forgivable in an actually serialized broadcast where new facts are being learned all the time. But it's clear that Reed had all the facts from the time Episode 1 was dropped, and was just dropping red herrings all over the place because it's lurid and draws people in.
What S-Town became ("a character study about a savant") was actually quite good. I feel like it would have been better if they had just focused on him rather than all those fantastic tertiary elements that never paid off.