I'll break down the Blood-C staff to explain what to expect.
How will it look?
Director: Tsutomu Mizushima (XXXHolic)
Original Character Design: CLAMP (XXXHolic)
Animation Character Design: Kazuchika Kise (XXXHolic)
Art Director: Hiromasa Ogura [Ogura Kobo] (XXXHolic)
Animation Production: Production IG (XXXHolic)
It will look like XXXHolic. In other words, pretty faithful visual adaptation of CLAMP's design.
How will it sound?
Music: Naoki Sato (Eureka 7, Sword of the Stranger)
The music will be awesome.
How will it animate?
Animation Director: Takayuki Goto (GitS:SAC, Moribito)
Editor: Junichi Uematsu (GitS:SAC, Moribito)
Animation Production: Production IG (GitS:SAC, Moribito)
Hopefully this means that it will animate as well as the more action packed Kamiyama P-IG shows. We'll need a trailer to be sure...
How will my brain leak out from my ears?
Original Concept: Production IG/CLAMP
Story/ Original Character Design: CLAMP
Original Concept Supervision: Junichi Fujisaku (Blood, Blood+, GitS:SAC, Real Drive)
Series Composition: Nanase Ohkawa [CLAMP]
Script: Nanase Ohkawa, Junichi Fujisaku (Blood, Blood+, GitS:SAC, Real Drive)
With CLAMP working so closely on a brand new original anime series not based on any of their manga for the first time ever, it will truly be something no one has seen before. Mix the potentially insane storytelling CLAMP can be known for along with the totally hit or miss Fujisaku who can write good scripts at one moment, and direct something totally worthless like Blood+ the next, and the result could be a story beyond our imagination.
Lolz.