It's not going to be pleasant, but change is going to happen. I predict that increased standards of living and dropping birth rates will be the big catalyst for change, and not revolutions. There will be reforms across the Mid East and lots of low-intensity violence. I'm certain that today's borders will not exist in a few decades, as countries are partitioned or consolidated due to religious differences.
The internet may also be a major factor in the secularization of the Middle East. Even though it's employed by groups like ISIS as a recruiting tool, its potential for education is much greater.
This is an unpopular opinion, but I actually think that ISIS is more of a "last hurrah" for Wahhabism than any long-term ideological threat. The only reason so many Muslims join ISIS is because these people fear the secularization of their home countries, either Europe or an Islamic republic. ISIS only exists to reclaim the alleged former glory of Islam, and counteract this perceived Western secular influence on the Middle East. The Taliban is the same shit. These organized Wahhabist groups are only able to obtain their power because some Muslims feel persecuted.
The inevitable death of ISIS will probably strike a pretty heavy blow against Wahhabist sentiment, at least among young Sunni Arabs, and I have no reason to believe that ISIS is capable of expanding much beyond its current area of control, which is really just a handful of large towns surrounded by largely depopulated desert.