Use shotugns, ideally Univ Remote and Felwinter Lie or really any other secondary shotty. Can definitely be done solo although even one more person can crack the efficiency to max by chaining supers, giving orbs to each other.
There are 16 majors (yellow health bars) you want to kill: 4 Goblins and 4 Hobgoblins on both the left and the right side. Ignore the Gatekeeper and all the red bar enemies. Run a clock wise circle, heading left from the spawn point. With Blue Polyphage, the 16 majors give 16*37 = 592 glimmer. By far the best farm spot in the game, as long as you can snag the CP (which is usually easy around here).