There still isn't a VR game that's actually worth putting an uncomfortable helmet on for.
This generation didn't give us anything new, but the generation before that didn't either, and the previous generation's games were even worse (360/PS3 gen was basically a gaming apocalypse it was so bad).
If I were forced to come up with a list of all the truly original seminal/influential games from 2000 onward, the list would be very short.
The Sims
Grand Theft Auto 3
Half-Life 2
World of Warcraft
Minecraft
Dark Souls
Fortnite
I'm not even saying those are good games (I like RE4 more than almost all of those, and you could definitely make an argument for its influence, but I don't feel that the game was truly huge). The games above were either the first excellent/mainstream implementation of a concept, enormously popular and influential, or just truly original. Even Half-Life 2 is a little shaky on this list. I put it there because it was super big and basically the game that sold people on physics engine integrations, but I'm not married to it making the cut.