Played for about 12 hours already and at Level 10 but haven't even visited Diamond City for the main story quest there yet. Too invested in exploring locations around Sanctuary and doing side quests around there as they appear.
I also seem to have a major hoarding problem. I'm seriously scrounging everywhere and keeping scraps to hoard back at Sanctaury for upgrades, but also means I'm constantly micro-managing the inventory of my character and my companions inventory just to avoid overencumberment lol.
Thankfully I'm on PC so I could just remove the weight limit via the ini files and carry a whole city's worth of junk on my person I guess hahaha.
Originally started on hard difficulty but found it too difficult which was surprising. Running at normal now and having a much more consistent path of progression, but I imagine I'll raise it back up again when I'm a bit more settled into the game and have better gear.
Performance wise I am noticing some areas of the game do push the hardware heavily. Drops down to around 50ish frames at worst, but so far they haven't been consistent enough to force me to drop below the preset for my rig (i5-2500K, GTX 970, 8 GB RAM), which is all Ultra except for High godrays. Always have the Geforce Experience optimised settings to work from to obtain more frames if I need them though I guess.
Funny how the Bethesda Fallout games hook me in instantly like this, yet I've never been able to get the same sort of thing out of any of the Elder Scrolls games.