Don't think so, but maybe?
There's two jobs E3 tends to have: let the press play what games and accessories are coming out that Christmas, and introduce the new games and hardware and technology which is coming in "the future".
"The future" has unfortunately been delayed until at least 2023 this gen, and I think September is a bad time to introduce brand new products which will not be available to buy this year. Summer events, that was okay, because you needed a hook-in title to get people buzzing while you show off your near-release games, but by September, you want to sell things.
So the CoD event and the Capcom event and the Disney event (which includes some games already out) make sense to me. They'll primarily focus on products you can buy or preorder soon after that show. Maybe they'll pepper in something crazy-new, but that probably won't be the focal point. And hopefully we'll get this damned God of War State of Play that we've been waiting and waiting on for a gameplay tour.
I feel like all of that happened over the Summer too, though (we've had a LOT of shows these past months) and I don't think these September shows will be so revelatory that it'll be the "real E3". (I also don't think TGS will have too much exciting, unless you're a Switch player and really like anime adaptations, because TGS just has not been an epicenter for major game showings even from Japanese studios for a little bit now.) But it's a moment to tune in at least... if you're not already exhausted by all the summer streams.