I felt that this was lacking a lot of the depth and intelligence of the comics. Obviously the comic has more time to flesh characters out, but I think the story the comics tell-a progression of six battles Scott needs to face, while he goes through regular relationship issues at the same time-simply isn't suited to the under-2-hours comedy film template. I would have adapted things differently and could talk for a long time about where I think emphasis was placed wrongly, the wrong stuff was cut/included, but ultimately this story probably needed to be radically reimagined to work in such a short film.
I also felt that by the end the effects-barrage had become numbing. The fights were cool, but lacking sufficient emotional grounding to remain truly interesting.
That said, there is a lot of energy and fun in here, especially in the first half. I did find the Seinfeld reference hilarious. Also interesting how a lot of the secondary jokes in the comic are great here, while the highlights of the comic sometimes fall a little flat. Speaks to the differences in the mediums.
The scene where the camera darts around everyone's faces at the Rockit, anime-style, was fantastic. Also, I loved the opening credits.
I must give credit to Edgar Wright as a director, because when I read a draft script of this a year ago (which the final version has improved-upon, but is still quite faithful to), much of the material was just dead on the page, but here it really comes to life.