Just finished my first playthrough, and have a feeling that a billion of the choices I made could make the whole game turn out entirely differently.
Gonna install some mods/hacks though for the subsequent playthroughs to make them faster now that i've got my "legit" runthrough done.
Great game, and so far the best of the year for me. It's a very fantastic game, plays well, I enjoy the combat system, and nothing feels extra. Everything is so well integrated, and it plays like a champ and looks gorgeous to boot. The controls handle very well and are very responsive, and felt great on M+KB, Dualshock 3, and 360 controller.
Not once did I die in combat and feel cheated. I always knew what my mistakes were and knew how to fix them the next time. I really enjoyed the combat system and its use of many different elements. Also shooting people off bridges with Aard was awesome, especially the way they screamed as they fell to their deaths.
Man, this is exciting. Overall, I finished my "Vanilla" playthrough at 55 hours, and spent a ton of time doing every quest I could find and crafting and making the best potions, traps, and gear. I also finished at level 46.