There is a very very small biological grey area with sex chromosomes and phenotypic sex expression.
Androgen (testosterone) insensitivity syndrome causes a XY fetus to not respond to testosterone appropriately, leading to the default feminine pathway. But they dont have a uterus or ovaries, just nonfunctional internal testes, so they are not complete biological women, just the closest "trans" woman you can probably achieve in nature. There is a spectrum for this condition as well, which might explain some cases of gender misalignment.
Jaime Lee Curtis is an example. I don't think anyone would hesitate to treat her as 100% female given that she has none of the male physical advantages and despite her inability to endure the most feminine of life's experiences (childbirth).
Androgen (testosterone) insensitivity syndrome causes a XY fetus to not respond to testosterone appropriately, leading to the default feminine pathway. But they dont have a uterus or ovaries, just nonfunctional internal testes, so they are not complete biological women, just the closest "trans" woman you can probably achieve in nature. There is a spectrum for this condition as well, which might explain some cases of gender misalignment.
Jaime Lee Curtis is an example. I don't think anyone would hesitate to treat her as 100% female given that she has none of the male physical advantages and despite her inability to endure the most feminine of life's experiences (childbirth).