Scourges have some voodoo-istic qualities when you kill them together; you have to kill the adds at the same time with them being the furthest possible distance away from each other (which actually isn't really that far, but just to be safe) this seems to increase the cast time of a special skill later in the fight.
soaking fireballs and giving Twintania stacks of waxen flesh during P2 increases the damage ceiling, size and knockback effects of individual twisters. the less stacks of waxen flesh Twintania recieves, twisters will no longer instagib and instead, deal real damage without the deathly knockbacks and knockups.
the Hygeia's damage debuff can be applied to Twintania to burn through P4 (twisters) as soon as possible as the positioning to safely dodge twisters is so wonky as to not get knocked into a wall or in front of Twintania, especially with a Dreadknight on the prowl. Asclepius doesn't seem to alter any mechanics.
at 25% Twintania loses her Slow debuff as the final chain breaks from her. at 10% Twintania splits into two and begins casting Mind Blast which will also instagib unless it's 3 targets, who are marked, are standing in their own Neurolink. This will never be cast on a tank. the placement of the third Neurolink is as important as the first two as this phase is also a DPS race as she counts down to Giga Flare, which seems to have a timer of 2 minutes when all Scourges are killed at the same time, far apart and 25-35 seconds without. Death Sentence is great fun on two tanks at the same time :/
good luck!