No, but they do feel a lot more natural with a bit of practice.
I made the mistake of playing on Normal my first time through The Wonderful 101. It's not fun to get mashed into the dirt at the same time you're trying to learn the controls and combat mechanics. Easy is definitely the better difficulty setting to start out with, regardless of your prior action game experience.
At its core TW101 is a more complex variation of Rock Paper Scissors, where each of your weapons can be a highly effective counter against certain attack types, or a tool to force enemies into vulnerable states. Watch
Saur's tutorials if you haven't already. It's important to know that each action has multiple functions, and what those functions do.