Is it possible to get by in most high end content with a controller?
The only scenarios that I feel like controller is a real barrier on:
- Healing outside your party in a 24-man alliance; there's some way to scroll through the alliance list but I don't do it enough to care so I end up just tabbing through a billion people
- 72 man PVP as a DPS, particularly Shatter. Targeting the crystal can be a struggle.
Neither is insurmountable, but both can be frustrating for control reasons.
Everything else is a matter of just working out crossbars that make sense to you, making use of extended bars, setting up target filtering, and adjusting the camera to Maximize tab target convenience.
Also Verminion kind of sucks on controller but nobody cares about Verminion.