Yeah, there's
Stylized ----- Semi-Realistic ----- Realistic
and everything between those.
That was due to technical limitations of the Wii Danjin, the eyes were basically painted on the character's faces, just like Final Fantasy 12.
You can tell a serious story, but probably have a really hard time to add more mature topics without it sounding too pretentious or weird (e.g. those anime/games that are cute but secretely dark and edgy)
For instance, imagine The Last of Us 2 scenes but with cute lolis and cute stylized faces. Yeah, that would creep people in an instant.
Anything that doesn't look like you average generic anime protagonist. I agree about Trails of Cold Steel and Tales Of characters, they have the same problem.