Here are my settings. These are based on a combination of research and my personal preferences, they are by no means definitive the best ever, just my opinion. My TV room has floor to ceiling windows with white blinds on three sides (back, front, right), so it is a very bright room.
The tools I used were the Pixar Maximizer and the Xbox One Picture Calibration:
My LG E6 Settings
ISF Expert (Bright Room)
Aspect Ratio - Original
Just Scan - On
OLED Light - 100
(Based this on rtings.com recommendation,
http://ca.rtings.com/tv/reviews/lg/e6/settings)
Contrast - 94
(Based this on Pixar Blu Ray Maximizer as well as Xbox One S calibration tool)
Brightness - 54
(Based this Maximizer, Xbox One S and Kill Bill 2 Blu Ray where she is about to be buried underground. The black sky will blend in with the borders with no over whitening. You could lower this within 5-10 points based on room settings, I have had it as low as 47)
H/V Sharpness - 10
(Based on AVForums YouTube vid -
https://www.youtube.com/watch?v=qFf4vEiHHRQ)
Color - 57
Personal preference. Anything between 50 and 60 should be fine.
Tint - 0
Personal preference, don't see any need to change.
Expert Controls
Dynamic Contrast - Off
Super Resolution - Off
Color Gamut - Normal
Edge Enhancer - Off
Color Filter - Off
Gamma - 2.2 (use what works best for you, I prefer a brighter pic)
White Balance
Color Temp - Cool (personal preference)
Method - 2 points
Red - 1
Green - 0
Blue - 5
(I won't bother posting 20 point for the sake of time, you gotta do some research here and find what works for you)
(RGB based on AVForums YouTube vid -
https://www.youtube.com/watch?v=qFf4vEiHHRQ)
Color Management
(No changes per on AVForums YouTube vid -
https://www.youtube.com/watch?v=qFf4vEiHHRQ)
Picture Options
Noise Reduction - Auto (this is my personal preference)
MPEG Noise Reduction - Off
Black Level - Low
Real Cinema - On
Motion Eye Care - Off
Tru Motion - User (De-Judder - 0, De-Blur - 10)