Played about an hour and so far seems good. Some brief hitching, audio mix seems weird (for me at least) in terms of volume levels and the odd small dialogue just being skipped or missing. Some faces have looked awkward in certain scenes but nothing major.
Graphically, it looks great in some places and good in others. I had to turn off 1 of the other shadow settings as shadows were popping and fading in like crazy. The shadows also look quite low resolution too, but I don't know if it's another setting I need to tweak (everything is maxed out apart from the previously mentioned optional shadow effect). I am playing in 32:9 aspect ratio so that maybe could also be an issue.
Regarding 32:9, I had to change the aspect ratio to "Free" to get it to fill the screen (it filled the screen on the main menu, but playing in game it switched to 21:9) The biggest pain was the seemingly optional PSN sign in, as I kept having to ALT Tab as it didn't pop up over the game screen and I kept getting that Windows error sound, but nothing crashed. It was just a bit messy. I don't know if it's a stylistic choice, but the subtitles can sometimes have this weird effect on them, making them break and kinda get distorted. I don't remember that from the original, but could be normal.
Some, I'm guessing, DLSS or frame gen can cause some pixelated effects for a few seconds on lighting and shadows. Haven't had an issue with colours etc The game still looks like I remember it so far, blue-ish and dark outside, while the Doctors room has started off warm and calm, while using HDR.
There are differences already with extra scenes and character placements etc but nothing drastic. The songs are different too, but nothing offensive yet, at least to me. Character models have changed slightly too on some characters and their voices seem a bit different, especially the Doctor. I haven't played the game since PS4 days, so maybe my memory is not accurate. Overall, looking forward to jumping back in.